1,4-Naphthoquinone-NH-C2-NH-Trolox

1,4-Naphthoquinone-NH-C2-NH-Trolox is a brain-penetrant Trolox (HY-101445) -vitamin K (HY-B2172) conjugate with neuroprotective activity. 1,4-Naphthoquinone-NH-C2-NH-Trolox can inhibit oxytosis, ferroptosis, ATP depletion and ROS production. 1,4-Naphthoquinone-NH-C2-NH-Trolox selective suppresses M1 markers expression. 1,4-Naphthoquinone-NH-C2-NH-Trolox can be used for the research of neurological disease, such as Alzheimer’s disease (AD) [1].

Product Specifications

UNSPSC

12352005

Target

Ferroptosis; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

O=C(C1(C)CCC2=C(O1)C(C)=C(C)C(O)=C2C)NCCNC(C3=O)=CC(C4=C3C=CC=C4)=O

Molecular Formula

C26H28N2O5

Molecular Weight

448.51

References & Citations

[1]He F, et al. Vitamin K-Trolox synergism realized in hybrid neuroprotectant with potent anti-ferroptosi/oxytosis activity, reduced toxicity, and in vivo efficacy in Alzheimer's disease mouse model. Eur J Med Chem. 2025 Dec 5;299:118068.