5-HT2A inverse agonist-1
5-HT2A inverse agonist-1 is a 5-HT2A receptor inverse agonist with a IC50 of 5.5 nM. 5-HT2A inverse agonist-1 shows minimal hERG inhibition. 5-HT2A inverse agonist-1 can be used for the research of neurological disease, such as Parkinson’s disease[1].
Product Specifications
CAS Number
3028943-38-3
UNSPSC
12352005
Target
5-HT Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
FC(C=C1)=CC=C1CN([C@@H]2[C@@H](CN(CC2)C)F)C(NCC3=CN=C(OCC(F)(F)F)C=C3)=O
Molecular Formula
C22H25F5N4O2
Molecular Weight
472.45
References & Citations
[1]Ma M, et al. Synthesis and evaluation of novel 5-HT2A receptor inverse agonist with excellent in vivo antipsychotic efficacy and superior tissue distribution for treatment of Parkinson's disease psychosis. Eur J Med Chem. 2025 Nov 15;298:118044.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT2 Receptor
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