5-HT2A inverse agonist-1

5-HT2A inverse agonist-1 is a 5-HT2A receptor inverse agonist with a IC50 of 5.5 nM. 5-HT2A inverse agonist-1 shows minimal hERG inhibition. 5-HT2A inverse agonist-1 can be used for the research of neurological disease, such as Parkinson’s disease[1].

Product Specifications

CAS Number

[3028943-38-3]

UNSPSC

12352005

Target

5-HT Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

FC(C=C1)=CC=C1CN([C@@H]2[C@@H](CN(CC2)C)F)C(NCC3=CN=C(OCC(F)(F)F)C=C3)=O

Molecular Formula

C22H25F5N4O2

Molecular Weight

472.45

References & Citations

[1]Ma M, et al. Synthesis and evaluation of novel 5-HT2A receptor inverse agonist with excellent in vivo antipsychotic efficacy and superior tissue distribution for treatment of Parkinson's disease psychosis. Eur J Med Chem. 2025 Nov 15;298:118044.