PRMT1-IN-3

PRMT1-IN-3 is a potent protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 4.11 μM. PRMT1-IN-3 inhibits PRMT6 and PRMT8 with IC50s of 23.3 and 30.1 μM. PRMT1-IN-3 suppresses asymmetric dimethylarginine (ADMA) levels and histone H4R3me2a modification in triple-negative breast cancer (TNBC) cells. PRMT1-IN-3 induces cell cycle arrest, apoptosis, and inhibits migration and colony formation in MDA-MB-231 cells. PRMT1-IN-3 acts as chemotherapeutic sensitizers for Paclitaxel (HY-B0015) . PRMT1-IN-3 can be used for the study of TNBC[1].

Product Specifications

CAS Number

[892570-48-8]

UNSPSC

12352101

Target

Apoptosis; Histone Methyltransferase

Related Pathways

Apoptosis; Epigenetics

Field of Research

Cancer

Smiles

FC1=CC=C(COC2=C(C=CC=C2)CNCCCNC)C=C1

Molecular Formula

C18H23FN2O

Molecular Weight

302.39

References & Citations

[1]Su Y, et al. Discovery of protein arginine methyltransferase 1 inhibitor by structure-based pharmacophore modeling, virtual screening, molecular dynamics simulations, and the enhancement of paclitaxel's antitumor activity. Eur J Med Chem. 2025 Dec 5;299:118066.