PD-166285
PD-166285 is a PKMYT1 inhibitor, with an IC50 value of 17 nM. PD166285 shows strong antiproliferative effects against CCNE1-amplified OVCAR3 cells (IC50 = 0.14 μM) and HCC1569 cells (IC50 = 0.21 μM) . PD166285 induces apoptosis and arrests CCNE1-amplified HCC1569 cells at the G1/S phase of the cell cycle. PD166285 can be used for the research of PKMYT1-targeted therapies for CCNE1-amplified cancers[1].
Product Specifications
CAS Number
717094-37-6
UNSPSC
12352005
Target
Apoptosis; Wee1
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
ClC1=CC=CC(Cl)=C1C2=CC3=C(N=C(NC4=CC=C(OCCN(C)C)C=C4)N=C3)N(C)C2=O
Molecular Formula
C24H23Cl2N5O2
Molecular Weight
484.38
References & Citations
[1]Zhang H, et al. Discovery of potent and selective PKMYT1 inhibitors for the treatment of CCNE1-amplified cancer. Eur J Med Chem. 2025 Dec 5;299:118059.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PKMYT1
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