APJ antagonist-1
APJ antagonist-1 is an apelin receptor (APJ) antagonist. APJ antagonist-1 shows strong β-arrestin inhibition with an IC50 of 3.1 μM. APJ antagonist-1 selectively inhibits APJ-overexpressing cancer cells and suppresses apelin-induced endothelial cell migration. APJ antagonist-1exhibits high metabolic stability. APJ antagonist-1 can used for the studies of ovarian cancer and tumor angiogenesis[1].
Product Specifications
UNSPSC
12352005
Target
Apelin Receptor (APJ)
Related Pathways
GPCR/G Protein
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=S(C1=CC=C([N+]([O-])=O)C=C1)(OC2=CC(CSC3=NC=CC=N3)=CC=C2OC)=O
Molecular Formula
C18H15N3O6S2
Molecular Weight
433.46
References & Citations
[1]Bist G, et al. Novel small molecule analogs for advancing apelin receptor antagonism with enhanced plasma and microsomal stability. Bioorg Med Chem Lett. 2025 Aug 8;129:130367.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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