PKMYT1-IN-10
PKMYT1-IN-10 is a selective PKMYT1 inhibitor with an IC50 of 3 nM. PKMYT1-IN-10 inhibits colony formation, induces apoptosis, and induces S-phase cancer cell cycle arrest. PKMYT1-IN-10 exhibits liver microsomal stability, favorable plasma stability, minimal CYPs inhibition. PKMYT1-IN-10 can be used for the studies of ovarian cancer and breast cancer[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Wee1
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
O=C(C1=CN=C(NC2=CC=C(S(=O)(C3CC3)=O)C=C2)N=C1N)NC4=C(C)C=CC(O)=C4C
Molecular Formula
C22H23N5O4S
Molecular Weight
453.51
References & Citations
[1]Zhang H, et al. Discovery of potent and selective PKMYT1 inhibitors for the treatment of CCNE1-amplified cancer. Eur J Med Chem. 2025 Dec 5;299:118059.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PKMYT1
Curated Selection
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