5-HT6R/FAAH modulator 1

5-HT6R/FAAH modulator 1 is a selective serotonin 5-HT6 receptor ligand and the fatty acid amide hydrolase (FAAH) enzyme inhibitor. 5-HT6R/FAAH modulator 1 shows a pKi of 6.33 (5-HT6) and a pIC50 valuesof 6.29 (FAAH) . 5-HT6R/FAAH modulator 1 also slightly inhibits acetylcholinesterase (AChE) or butyrylcholinesterase (BChE) enzymes (pIC50 = 5.12) . 5-HT6R/FAAH modulator 1 can inhibit apoptosis and reduce ROS levels. 5-HT6R/FAAH modulator 1 can be used for the research of neurological disease, such as Alzheimer’s disease (AD) [1].

Product Specifications

UNSPSC

12352005

Target

5-HT Receptor; Apoptosis; FAAH; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

NC1=NC(COC2=CC(C)=CC=C2C)=NC(N3CCN(CC4=CC=C(OC)C(OC)=C4OC)CC3)=N1

Molecular Formula

C26H34N6O4

Molecular Weight

494.59

References & Citations

[1]Czarnota-Łydka K, et al. The first-in-class 1,3,5-triazine-derived dual 5-HT6R/FAAH modulators in search for potential drug against neurodegenerative diseases with cognitive impairment. Eur J Med Chem. 2025 Nov 15;298:118026.