Apoptosis inducer 44
Apoptosis inducer 44 is an apoptosis inducer. Apoptosis inducer 44 triggers apoptosis in MDA-MB-231 cells by increasing the levels of Bax and Cyt C, reducing Bcl-2, and initiating caspase-3 cleavage. Apoptosis inducer 44 suppresses the invasion and migration of MDA-MB-231 cells by down-regulating MMP-2 and MMP-9 expression and up-regulating E-cadherin protein levels. Apoptosis inducer 44 can be used for the study of breast cancer[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Cadherin; Caspase; MMP
Related Pathways
Apoptosis; Cytoskeleton; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
OC1=CC=C(/C=C/C(C=C)(C)CC/C=C(C)\C)C=C1C(N2CCCCC2)C3=CC(F)=C(F)C(F)=C3
Molecular Formula
C30H36F3NO
Molecular Weight
483.61
References & Citations
[1]Li HM, et al. Synthesis and anti-breast cancer evaluation of new bakuchiol derivatives. Bioorg Med Chem Lett. 2025 Dec 1;128:130361.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bax; Bcl-2; Caspase 3; MMP-2; MMP-9
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