NPSR1 antagonist-1
NPSR1 antagonist-1 is a potent and peripherally restricted neuropeptide S receptor 1 (NPSR1) antagonist. NPSR1 antagonist-1 can inhibit IL-6, PTGS2, IL-20, and CXCL8 expression. NPSR1 antagonist-1 can reduce TNF-α cytokine levels. NPSR1 antagonist-1 can be used for the research of inflammation, such as peritonitis[1].
Product Specifications
UNSPSC
12352005
Target
Interleukin Related; Neuropeptide S Receptor; TNF Receptor
Related Pathways
Apoptosis; GPCR/G Protein; Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
O=C(C1CCCCC1)N(CC2(N3CCN(C)CC3)CCC(F)(F)CC2)CC4=CC5=C(N(C)C4=O)C=CC=C5
Molecular Formula
C30H42F2N4O2
Molecular Weight
528.68
References & Citations
[1]Berger KJ, et al. Design of a peripherally biased NPSR1 antagonist for neuropeptide S induced inflammation. Bioorg Med Chem Lett. 2025 Dec 1;128:130353.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-6
Curated Selection
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