MU876
MU876 (Compound 32) is a MUS81 inhibitor with an IC50 of 0.5 μM. MU876 effectively inhibits MUS81-dependent homologous recombination (HR) and break-induced replication (BIR) pathways. MU876 sensitizes cancer cells to DNA-damaging agents, such as Cisplatin (HY-17394), through impairing their ability to repair DNA lesions. MU876 can be used for cancers chemotherapy research[1].
Product Specifications
CAS Number
[1208829-24-6]
UNSPSC
12352005
Target
Endonuclease
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(C1=NOC(C2=CC=CC=C2)=C1)NC3=CC(C4=CC=CC=C4)=NN3C5=NC(C)=CC(N5)=O
Molecular Formula
C24H18N6O3
Molecular Weight
438.44
References & Citations
[1]Prochazkova J, et al. Discovery of two structurally distinct classes of inhibitors targeting the nuclease MUS81 and enhancing efficacy of chemotherapy in cancer cells[J]. bioRxiv, 2025: 2025.07. 25.666773.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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