Ferroptosis inducer-10
Ferroptosis inducer-10 is a ferroptosis inducer. Ferroptosis inducer-10 can inhibit A549 cells growth with an IC50 of 0.76 μM. Ferroptosis inducer-10 can deplete GSH, elevate ROS and MDA, and downregulate GPX4 expression. Ferroptosis inducer-10 can induce cell G2/M phase and inhibit migration. Ferroptosis inducer-10 can be used for the research of cancer, such as non-small lung cancer[1].
Product Specifications
UNSPSC
12352005
Target
Ferroptosis; Glutathione Peroxidase
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C1C(NC2=CC=CC3=C2C=CC=N3)CC(C4=CC=CC=C41)=O
Molecular Formula
C19H14N2O2
Molecular Weight
302.33
References & Citations
[1]Yang H, et al. Scaffold-leaping optimization of naphthoquinone derivatives as ferroptosis inducer against non-small lung cancer. Bioorg Med Chem Lett. 2025 Aug 7;129:130360.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GPX4
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