Ferroptosis inducer-10

Ferroptosis inducer-10 is a ferroptosis inducer. Ferroptosis inducer-10 can inhibit A549 cells growth with an IC50 of 0.76 μM. Ferroptosis inducer-10 can deplete GSH, elevate ROS and MDA, and downregulate GPX4 expression. Ferroptosis inducer-10 can induce cell G2/M phase and inhibit migration. Ferroptosis inducer-10 can be used for the research of cancer, such as non-small lung cancer[1].

Product Specifications

UNSPSC

12352005

Target

Ferroptosis; Glutathione Peroxidase

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C1C(NC2=CC=CC3=C2C=CC=N3)CC(C4=CC=CC=C41)=O

Molecular Formula

C19H14N2O2

Molecular Weight

302.33

References & Citations

[1]Yang H, et al. Scaffold-leaping optimization of naphthoquinone derivatives as ferroptosis inducer against non-small lung cancer. Bioorg Med Chem Lett. 2025 Aug 7;129:130360.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

GPX4

Curated Selection

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