GSPT1 degrader-8
GSPT1 degrader-8 is a potent and orally active G1 to S phase transition 1 (GSPT1) molecular glue degrader. GSPT1 degrader-8 induces GSPT1 degradation and inhibits tumor growth. GSPT1 degrader-8 can be used for the research of cancer, such as breast cancer[1].
Product Specifications
UNSPSC
12352005
Target
Molecular Glues
Related Pathways
PROTAC
Field of Research
Cancer
Smiles
O=C(C1=CC2=C(CCC2)C=C1)NCC3=C4C5=C(N(C(CC6)C(NC6=O)=O)C(C5=CC=C4)=O)C=C3
Molecular Formula
C27H23N3O4
Molecular Weight
453.49
References & Citations
[1]Gao RD, et al. Identification of potent and orally bioavailable GSPT1 molecular glue degraders. Bioorg Med Chem Lett. 2025 Aug 16;129:130375.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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