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GSPT1 degrader-8

GSPT1 degrader-8 is a potent and orally active G1 to S phase transition 1 (GSPT1) molecular glue degrader. GSPT1 degrader-8 induces GSPT1 degradation and inhibits tumor growth. GSPT1 degrader-8 can be used for the research of cancer, such as breast cancer[1].

Product Specifications

UNSPSC

12352005

Target

Molecular Glues

Related Pathways

PROTAC

Field of Research

Cancer

Smiles

O=C(C1=CC2=C(CCC2)C=C1)NCC3=C4C5=C(N(C(CC6)C(NC6=O)=O)C(C5=CC=C4)=O)C=C3

Molecular Formula

C27H23N3O4

Molecular Weight

453.49

References & Citations

[1]Gao RD, et al. Identification of potent and orally bioavailable GSPT1 molecular glue degraders. Bioorg Med Chem Lett. 2025 Aug 16;129:130375.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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