VF-57a
VF-57a (Compound 23) is an Influenza A virus (IAV) fusion inhibitor. VF-57 has potent antiviral activities against authentic A/H1N1 virus with EC50s of 0.92 and 0.31 μM for the A/H1N1 PR8 and A/H1N1 Virg09 strains, respectively. VF-57 significantly inhibits HA-mediated cell entry of A/H1N1- and A/H5N1-pseudoviruses, prevents the HA refolding at pH 5.2. VF-57a can be used for IAV infections research[1].
Product Specifications
UNSPSC
12352005
Target
Influenza Virus
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
O=C(NCC1=C(C)SC(C)=C1)C2=CC(C(F)(F)F)=CC(Cl)=C2
Molecular Formula
C15H13ClF3NOS
Molecular Weight
347.78
References & Citations
[1]Rimaux S, et al. N-[ (Thiophen-3-yl) methyl] benzamides as Influenza Virus Fusion Inhibitors Acting on H1 and H5 Hemagglutinins[J]. bioRxiv, 2025: 2025.07. 28.667118.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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