CS47
CS47 is a reversible Thioredoxin reductase 1 (TrxR1) inhibitor. CS47 activates stress-responsive GSH and iron regulatory programs, depleting GSH and promoting HO-1 overexpression and intracellular iron overload by ROS accumulation, and finally inducing ferroptosis in KRAS-independent lung cancers. CS47 has an anticancer activity with low cytotoxicity toward normal lung fibroblasts[1].
Product Specifications
CAS Number
1372792-51-2
UNSPSC
12352005
Target
Ferroptosis; Reactive Oxygen Species (ROS) ; TrxR
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer
Smiles
ClC1=C(Cl)[N-]([Au+][P](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)C=N1
Molecular Formula
C21H16AuCl2N2P
Molecular Weight
595.21
References & Citations
[1]Andreani C, et al. Thioredoxin Reductase 1 inhibition triggers ferroptosis in KRAS-independent lung cancers. bioRxiv [Preprint]. 2025 Jul 30:2025.07.25.666783.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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