M2 ion channel blocker-2

M2 ion channel blocker-2 (Compound 10) is a M2 channel blocker. M2 ion channel blocker-2 significantly blocks wild-type and mutant M2 (L27F and V27A) ion channels. M2 ion channel blocker-2 has potent antiviral activity against HCoV-229E (EC50: 4.7 μM in cytopathic effect) but not against influenza A virus. M2 ion channel blocker-2 has no significant inhibition of hERG and cytochrome P450 (CYP1A2, CYP2C19, and CYP3A4) activity[1].

Product Specifications

CAS Number

[2260797-32-6]

UNSPSC

12352211

Target

SARS-CoV

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

NC12C[C@]3(C)C4(C)CC1CC4(C)C3(C)C2

Molecular Formula

C14H23N

Molecular Weight

205.34

References & Citations

[1]Turcu A L, et al. Exploring polycyclic scaffolds as adamantane replacements in M2 channel inhibitors of Influenza A virus[J]. bioRxiv, 2025: 2025.07. 26.666854.