X15695

X15695 is selective and orally active estrogen receptor (ERα) degrader. X15695 is an aryl hydrocarbon receptor (AHR) ligand. X15695 enables AHR to form a complex with the ERα, promoting its proteasomal degradation. X15695 inhibits the breast cancer cells proliferation, promotes cell cycle block and induces apoptosis. X15695 can be used for the study of breast cancer[1][2].

Product Specifications

CAS Number

[353258-25-0]

UNSPSC

12352005

Target

Apoptosis; Aryl Hydrocarbon Receptor; Estrogen Receptor/ERR; MDM-2/p53

Related Pathways

Apoptosis; Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

98.45

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC(C1=CN2C(C(Cl)=C1)=NC(C3=CC=C(F)C=C3)=C2)(F)F

Molecular Formula

C14H7ClF4N2

Molecular Weight

314.67

References & Citations

[1]Katrin Koellisch, et al. Distinct 2-phenyl-imidazo[1, 2α] pyridine derivatives drive ER degradation and selectively impair proliferation of ER breast cancer cells via the aryl hydrocarbon receptor+. 2025 Aug 1|[2]Pan M, et al. Identification of an Imidazopyridine-based Compound as an Oral Selective Estrogen Receptor Degrader for Breast Cancer Therapy. Cancer Res Commun. 2023 Jul 27;3 (7) :1378-1396.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

ERα

Available Sizes

Curated Selection

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