CB2R antagonist 4
CB2R antagonist 4 is a selective CB2R antagonist/inverse agonist with a pKi of 6.54. CB2R antagonist 4 shows a ≥11-fold selectivity towards CB2R over CB1R and can be utilized in neurological research[1].
Product Specifications
CAS Number
1341021-90-6
UNSPSC
12352005
Target
Cannabinoid Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(C1=CC=C2C(N(CC3=CC=C(C=C3)F)C(C4=CC=NN42)=O)=C1)NC5=CC(F)=CC=C5F
Molecular Formula
C24H15F3N4O2
Molecular Weight
448.40
References & Citations
[1]Scharf MM, et al. Water molecules in the cannabinoid receptor 2 binding site crucially impact the discovery of novel ligands. Eur J Med Chem. 2025 Dec 5;299:117846.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CB2
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