CB2R antagonist 4

CB2R antagonist 4 is a selective CB2R antagonist/inverse agonist with a pKi of 6.54. CB2R antagonist 4 shows a ≥11-fold selectivity towards CB2R over CB1R and can be utilized in neurological research[1].

Product Specifications

CAS Number

[1341021-90-6]

UNSPSC

12352005

Target

Cannabinoid Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O=C(C1=CC=C2C(N(CC3=CC=C(C=C3)F)C(C4=CC=NN42)=O)=C1)NC5=CC(F)=CC=C5F

Molecular Formula

C24H15F3N4O2

Molecular Weight

448.40

References & Citations

[1]Scharf MM, et al. Water molecules in the cannabinoid receptor 2 binding site crucially impact the discovery of novel ligands. Eur J Med Chem. 2025 Dec 5;299:117846.