MM927
MM927 is a potent NVL inhibitor, with an IC50 of 0.053 μM. MM927 blocks 60S ribosomal subunit biogenesis in the nucleolus. MM927 induces half-mer polysomes, cell cycle arrest at G1/S and G2/M and apoptosis in cells. MM927 demonstrates antitumor efficacy in MOLM-13 AML and HCT116 CRC xenograft models. MM927 can be used for the study of cancers such as acute myeloid leukemia (AML) and colorectal cancer (CRC) [1].
Product Specifications
CAS Number
3065567-21-4
UNSPSC
12352005
Target
Apoptosis
Related Pathways
Apoptosis
Field of Research
Cancer
Smiles
O=C1OC2=CC=C(C(NC3=CC=C4C(SC5=CC(F)=CC=C5C(N4CC#CC)=O)=C3)=O)C=C2N1C
Molecular Formula
C26H18FN3O4S
Molecular Weight
487.50
References & Citations
[1]Guo HH, et al. A small molecule inhibitor of NVL suppresses tumor growth by blocking ribosome biogenesis. bioRxiv [Preprint]. 2025 Aug 1:2025.07.31.667081.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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