MM927

MM927 is a potent NVL inhibitor, with an IC50 of 0.053 μM. MM927 blocks 60S ribosomal subunit biogenesis in the nucleolus. MM927 induces half-mer polysomes, cell cycle arrest at G1/S and G2/M and apoptosis in cells. MM927 demonstrates antitumor efficacy in MOLM-13 AML and HCT116 CRC xenograft models. MM927 can be used for the study of cancers such as acute myeloid leukemia (AML) and colorectal cancer (CRC) [1].

Product Specifications

CAS Number

[3065567-21-4]

UNSPSC

12352005

Target

Apoptosis

Related Pathways

Apoptosis

Field of Research

Cancer

Smiles

O=C1OC2=CC=C(C(NC3=CC=C4C(SC5=CC(F)=CC=C5C(N4CC#CC)=O)=C3)=O)C=C2N1C

Molecular Formula

C26H18FN3O4S

Molecular Weight

487.50

References & Citations

[1]Guo HH, et al. A small molecule inhibitor of NVL suppresses tumor growth by blocking ribosome biogenesis. bioRxiv [Preprint]. 2025 Aug 1:2025.07.31.667081.