MM927
MM927 is a potent NVL inhibitor, with an IC50 of 0.053 μM. MM927 blocks 60S ribosomal subunit biogenesis in the nucleolus. MM927 induces half-mer polysomes, cell cycle arrest at G1/S and G2/M and apoptosis in cells. MM927 demonstrates antitumor efficacy in MOLM-13 AML and HCT116 CRC xenograft models. MM927 can be used for the study of cancers such as acute myeloid leukemia (AML) and colorectal cancer (CRC) [1].
Product Specifications
CAS Number
3065567-21-4
UNSPSC
12352005
Target
Apoptosis
Related Pathways
Apoptosis
Field of Research
Cancer
Smiles
O=C1OC2=CC=C(C(NC3=CC=C4C(SC5=CC(F)=CC=C5C(N4CC#CC)=O)=C3)=O)C=C2N1C
Molecular Formula
C26H18FN3O4S
Molecular Weight
487.50
References & Citations
[1]Guo HH, et al. A small molecule inhibitor of NVL suppresses tumor growth by blocking ribosome biogenesis. bioRxiv [Preprint]. 2025 Aug 1:2025.07.31.667081.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
orb2449338 100 µL
Phospho-STAT3 (Tyr705) Rabbit Polyclonal Antibody (APC-Cy7)
Sign In for Pricing
View Details 
MBS8510480-02 0.1 mL (AF635)
Flotillin-2 Rabbit Polyclonal Antibody
Sign In for Pricing
View Details MBS8510480-03 0.1 mL (AF610)
Flotillin-2 Rabbit Polyclonal Antibody
Sign In for Pricing
View Details