CHI3L1-IN-4
CHI3L1-IN-4 (Compound 8) is a Chitinase-3-Like Protein 1 (CHI3L1) inhibitor with a Kd of 6.8 μM. CHI3L1-IN-4 significantly reduces glioblastoma (GBM) spheroids viability and attenuates phospho-STAT3 levels by disrupting CHI3L1 pathway. CHI3L1-IN-4 can be used for GBM research[1].
Product Specifications
CAS Number
1258696-85-3
UNSPSC
12352005
Target
Glycosidase; STAT
Related Pathways
JAK/STAT Signaling; Metabolic Enzyme/Protease; Stem Cell/Wnt
Field of Research
Cancer
Smiles
CSC1=NN=C(S1)CNC(C2=CC=CC=C2)C3=CC=CC=C3
Molecular Formula
C17H17N3S2
Molecular Weight
327.47
References & Citations
[1]Kaur B, et al. Virtual Screening-Guided Discovery of Small Molecule CHI3L1 Inhibitors with Functional Activity in Glioblastoma Spheroids. bioRxiv [Preprint]. 2025 Aug 1:2025.07.31.667816.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT3
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