TDP1-IN-4
TDP1-IN-4 (Compound 33) is a Tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitor with an IC50 of 0.90 μM. TDP1-IN-4 has a strong synergistic effect with Camptothecin (HY-16560) in SK-Mel-2 cells, but not in cancer cells (A549, HCT-116 and MCF-7 cells) and non-cancerous Ges-1 cells. TDP1-IN-4 can be used for cancer chemotherapy and radiotherapy research[1].
Product Specifications
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=C(N(CC1=CC=C(/C=C/C(O)=O)C=C1)[C@H]2CC3=C(C(C=C)(C)C)NC4=C3C=C(C/C=C(C)\C)C=C4C/C=C(C)\C)[C@H](C)N(CC5=CC=C(/C=C/C(O)=O)C=C5)C2=O
Molecular Formula
C49H55N3O6
Molecular Weight
781.98
References & Citations
[1]Yao CS, et al. Discovery, structural modification and structure-activity relationship study of Echinulin derivatives as tyrosyl-DNA phosphodiesterase 1 inhibitors and their potential antitumor activity. Eur J Med Chem. 2025 Nov 15;298:118040.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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