MIDH1-IN-2
MIDH1-IN-2 is a brain-penetrant isocitrate dehydrogenase 1 (IDH1) inhibitor. mIDH1-IN-2 shows subnanomolar potency against IDH1 R132H and R132C (IC50 = 80.0 and 58.0 nM) and minimal activity against wt-IDH1/2. mIDH1-IN-2 also inhibits PDK1 (IC50 = 0.61 μM) and reduces PDH phosphorylation dose-dependently. mIDH1-IN-2 can inhibit cells proliferation, induces S phase arrest and promotes apoptosis. mIDH1-IN-2 can be used for the research of cancer, such as glioma[1].
Product Specifications
UNSPSC
12352100
Target
Apoptosis; Isocitrate Dehydrogenase (IDH) ; PDK-1
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
O=C(C1=CC=C(SC2=CC=CC(OC3CCC3)=C2)C([N+]([O-])=O)=C1)C(Br)Br
Molecular Formula
C18H15Br2NO4S
Molecular Weight
501.19
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IDH1
Frequently Asked Questions
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