PROTAC BRD4 Degrader-39

PROTAC BRD4 Degrader-39 is a selective targeting Bromodomain protein 4 (BRD4) degrader with an DC50 value of 24.66 nM. PROTAC BRD4 Degrader-39 conjugates BRD PROTAC (ARV-771) (HY-100972) with carbohydrate. PROTAC BRD4 Degrader-39 selectively delivers to tumor cells with high GLUT1 expression, followed by GSH-triggered release of ARV-771 and degrades BRD4. PROTAC BRD4 Degrader-39 can inhibit tumor growth and show no significant toxicity. PROTAC BRD4 Degrader-39 can be used for the research of cancer, such as breast cancer[1]. (Structure Note: Pink: BRD4 ligand (HY-78695) ; Blue: VHL ligand (HY-112078) ; Black: (HY-42427) ; BRD4 ligand-Linker: (HY-42429) )

Product Specifications

UNSPSC

12352005

Target

Epigenetic Reader Domain; PROTACs

Related Pathways

Epigenetics; PROTAC

Field of Research

Cancer

Smiles

CC1=C(C)SC2=C1C(C3=CC=C(C=C3)Cl)=N[C@H](C4=NN=C(N42)C)CC(NCCOCCCOCC(N[C@H](C(N5C[C@@H](C[C@H]5C(N[C@@H](C)C6=CC=C(C=C6)C7=C(C)N=CS7)=O)OC(OCCSSCCN8C=C(N=N8)CO[C@@H]([C@@H]9O)O[C@H](CO)[C@H](O)C9O)=O)=O)C(C)(C)C)=O)=O

Molecular Formula

C63H81ClN12O15S4

Molecular Weight

1410.10

References & Citations

[1]Gao Y, et al. GLUTs-Facilitated Targeting BRD4 Degradation in Breast Cancer through Carbohydrate-Conjugated PROTACs. J Med Chem. 2025 Aug 28;68 (16) :17046-17064.