CRBN Ligand-Linker Conjugate 2
CRBN Ligand-Linker Conjugate 2 is a synthesized E3 ligand-linker conjugate that can be used for synthesis of PROTACs, such as FIP22 (HY-175764) . FIP22 is a potent and selective IRAK4 PROTAC degrader with anti- atopic dermatitis activity[1].
Product Specifications
CAS Number
[2476319-08-9]
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Related Pathways
PROTAC
Field of Research
Inflammation/Immunology
Smiles
O=C(CC1)NC(C1N(C2=O)C(C(C2=C3)=CC=C3N(CC4)CCC54CCNCC5)=O)=O
Molecular Formula
C22H26N4O4
Molecular Weight
410.47
References & Citations
[1]Fan Y, et al. Discovery of Rigid Linker-Based IRAK4 PROTACs with Improved Metabolic Stability for the Treatment of Inflammatory Diseases. J Med Chem. 2025 Aug 28;68 (16) :17874-17896.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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