CRBN Ligand-Linker Conjugate 2

CRBN Ligand-Linker Conjugate 2 is a synthesized E3 ligand-linker conjugate that can be used for synthesis of PROTACs, such as FIP22 (HY-175764) . FIP22 is a potent and selective IRAK4 PROTAC degrader with anti- atopic dermatitis activity[1].

Product Specifications

CAS Number

[2476319-08-9]

UNSPSC

12352005

Target

E3 Ligase Ligand-Linker Conjugates

Related Pathways

PROTAC

Field of Research

Inflammation/Immunology

Smiles

O=C(CC1)NC(C1N(C2=O)C(C(C2=C3)=CC=C3N(CC4)CCC54CCNCC5)=O)=O

Molecular Formula

C22H26N4O4

Molecular Weight

410.47

References & Citations

[1]Fan Y, et al. Discovery of Rigid Linker-Based IRAK4 PROTACs with Improved Metabolic Stability for the Treatment of Inflammatory Diseases. J Med Chem. 2025 Aug 28;68 (16) :17874-17896.