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Riboswit-modulator-1

Riboswit-modulator-1 (Compound A1), a covalent RNA ligand, is a bacterial Flavin mononucleotide (FMN) riboswitch modulator. Riboswit-modulator-1 modifies unpaired guanine residues (G11 and G62) proximal to the FMN-binding site through a proximity-driven mechanism, and interferes with its conformational transitions. Riboswit-modulator-1 acts as a negative antagonist by eliciting the opposite effect of the natural effector molecule[1].

Product Specifications

UNSPSC

12352005

Target

Bacterial

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

CC1=CC2=C(N=C(C(N3)=O)C(N2CCNC4=CC=C(C(C(O)O)=O)C=C4)=NC3=O)C=C1C

Molecular Formula

C22H21N5O5

Molecular Weight

435.43

References & Citations

[1]Li C, et al. Structure-Guided Design of a Bioactive Covalent Small Molecule Targeting a Riboswitch. bioRxiv [Preprint]. 2025 Aug 2:2025.08.01.668122.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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