Riboswit-modulator-1
Riboswit-modulator-1 (Compound A1), a covalent RNA ligand, is a bacterial Flavin mononucleotide (FMN) riboswitch modulator. Riboswit-modulator-1 modifies unpaired guanine residues (G11 and G62) proximal to the FMN-binding site through a proximity-driven mechanism, and interferes with its conformational transitions. Riboswit-modulator-1 acts as a negative antagonist by eliciting the opposite effect of the natural effector molecule[1].
Product Specifications
UNSPSC
12352005
Target
Bacterial
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
CC1=CC2=C(N=C(C(N3)=O)C(N2CCNC4=CC=C(C(C(O)O)=O)C=C4)=NC3=O)C=C1C
Molecular Formula
C22H21N5O5
Molecular Weight
435.43
References & Citations
[1]Li C, et al. Structure-Guided Design of a Bioactive Covalent Small Molecule Targeting a Riboswitch. bioRxiv [Preprint]. 2025 Aug 2:2025.08.01.668122.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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