EN1033
EN1033 is a covalent immune regulatory transcription factor 5/8 (IRF5/8) molecular glue degrader. EN1033 degrades IRF5 in a proteasome-dependent manner. EN1033 engages and degrades IRF8 more robustly and rapidly. EN1033 covalently targets C28 and C223 to destabilize and degrade IRF5 and IRF8 respectively, thereby inhibiting their pro-inflammatory transcriptional activity. EN1033 serves as a promising tool for the study of autoimmune and inflammatory disorders[1].
Product Specifications
CAS Number
2193367-28-9
UNSPSC
12352005
Target
IFNAR; Molecular Glues
Related Pathways
Immunology/Inflammation; PROTAC
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Purity
99.96
Smiles
C=CC(N1C2=CC=CC=C2CN3C(CCC3)C1)=O
Molecular Formula
C15H18N2O
Molecular Weight
242.32
References & Citations
[1]Do TC, et al. Covalent Degraders of Immune Regulatory Transcription Factors IRF8 and IRF5. bioRxiv [Preprint]. 2025 Aug 3:2025.08.03.668300.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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