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AChE-IN-94

AChE-IN-94 is an orally active and blood-brain barrier penetrable AChE inhibitor with an IC50 of 0.40 μM and Ki of 0.28 μM. AChE-IN-94 prevents self-induced and AChE-mediated Aβ1-42 aggregation. AChE-IN-94 alleviates cognitive/memory deficits in Scopolamine -induced amnesic model. AChE-IN-94 can be used for the study of Alzheimer's disease (AD).

Product Specifications

UNSPSC

12352005

Target

Amyloid-β; Cholinesterase (ChE)

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

O=C(NC1=NC2=CC=C(Cl)C=C2S1)CN3CCN(C(C4=CC=C(F)C=C4)=O)CC3

Molecular Formula

C20H18ClFN4O2S

Molecular Weight

432.90

References & Citations

[1]Bhardwaj B, et al. Novel benzothiazole-based cholinesterase inhibitors with amyloid beta disaggregation and antioxidant activity against Alzheimer's disease. Eur J Med Chem. 2025 Nov 15;298:118047.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

AChE

Frequently Asked Questions

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