SMARCA2/4 degrader-1
SMARCA2/4 degrader-1 (Compound 1) is a SMARCA2/4 molecular glue degrader with a DC50 of 2.2 nM for SMARCA4. SMARCA2/4 degrader-1 covalently recruits both CUL4DCAF16 and CRL1FBXO22 to degrade SMARCA2/4[1].
Product Specifications
CAS Number
[2901804-87-1]
UNSPSC
12352005
Target
Epigenetic Reader Domain; Molecular Glues
Related Pathways
Epigenetics; PROTAC
Field of Research
Cancer
Smiles
OC1=CC=CC=C1C2=CC(N3CC4N(C5=CC(C#CCN6CCCCCC6)=NC=C5)C(CC4)C3)=C(N)N=N2
Molecular Formula
C30H35N7O
Molecular Weight
509.65
References & Citations
[1]Spiteri V A, et al. Dual E3 ligase recruitment by monovalent degraders enables redundant and tuneable degradation of SMARCA2/4[J]. bioRxiv, 2025: 2025.08. 04.668513.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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