BMS-986463
BMS-986463, a CRBN E3 ligase modulator (CELMoD), is a WEE1 kinase molecular glue degrader. BMS-986463 significantly inhibits tumor regression and reduces the level of phospho-CDK2. BMS-986463 can be used for advanced malignant solid tumors like non-small cell lung cancer (NSCLC) research[1].
Product Specifications
CAS Number
3025467-07-3
UNSPSC
12352005
Target
Wee1
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
99.51
Solubility
DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1CC[C@@H](C(N1)=O)N2CC3=CC(O[C@H]4CCN(C4)CC5=CC(F)=C6N=C(C=CC6=C5)C7CCOCC7)=CC=C3C2=O
Molecular Formula
C32H33FN4O5
Molecular Weight
572.63
References & Citations
[1]Jennifer R, et al. Discovery of a first-in-class molecular glue degrader of WEE1 kinase, BMS-986463, for the treatment of advanced malignant solid tumors. ACS. 2025 Aug 20.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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