BMS-986463

BMS-986463, a CRBN E3 ligase modulator (CELMoD), is a WEE1 kinase molecular glue degrader. BMS-986463 significantly inhibits tumor regression and reduces the level of phospho-CDK2. BMS-986463 can be used for advanced malignant solid tumors like non-small cell lung cancer (NSCLC) research[1].

Product Specifications

CAS Number

3025467-07-3

UNSPSC

12352005

Target

Wee1

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Purity

99.51

Solubility

DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1CC[C@@H](C(N1)=O)N2CC3=CC(O[C@H]4CCN(C4)CC5=CC(F)=C6N=C(C=CC6=C5)C7CCOCC7)=CC=C3C2=O

Molecular Formula

C32H33FN4O5

Molecular Weight

572.63

References & Citations

[1]Jennifer R, et al. Discovery of a first-in-class molecular glue degrader of WEE1 kinase, BMS-986463, for the treatment of advanced malignant solid tumors. ACS. 2025 Aug 20.