PSMA-MAL-5
PSMA-MAL-5 is a PSMA ligand. PSMA-MAL-5 covalently binds to Cys466 of PSMA. PSMA-MAL-5 labeled with 177Lu and 225Ac has high radiostability and tumor uptake. PSMA-MAL-5 also effectively inhibits tumor growth. PSMA-MAL-5 can be used for SPECT/CT imaging and radionuclide therapy of prostate cancer[1].
Product Specifications
CAS Number
[3077205-52-5]
UNSPSC
12352005
Target
PSMA
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C([C@@H]1CC[C@H](CC1)CNC([C@H](CCCCNC(CN2CCN(CCN(CCN(CC2)CC(O)=O)CC(O)=O)CC(O)=O)=O)NC(CCCCCN3C(C=CC3=O)=O)=O)=O)N[C@H](C(NCCCC[C@@H](C(O)=O)NC(N[C@H](C(O)=O)CCC(O)=O)=O)=O)CC4=CC=CC5=C4C=CC=C5
Molecular Formula
C65H94N12O20
Molecular Weight
1363.51
References & Citations
[1]Yong W, et al. Click Covalent-Targeted Radionuclide Therapy for Prostate Cancer. J Med Chem. 2025 Aug 28;68 (16) :17794-17807.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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