IID432
IID432 is a Trypanosoma cruzi Topoisomerase II inhibitor with an EC50 of 8 nM for Trypanosoma cruzi. IID432, a single dose of 25 mg/kg, can achieve relapse-free parasite clearance in mouse models of chronic Chagas disease. IID432 can be used for Chagas disease research[1].
Product Specifications
UNSPSC
12352005
Target
Parasite; Topoisomerase
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Smiles
CC1=NC2=C(C=C(C=C2)N3CC[C@@H](C3)NC(CN4C=NC(C#N)=N4)=O)C=C1
Molecular Formula
C19H19N7O
Molecular Weight
361.40
References & Citations
[1]H Rachel Lagiakos, et al. Discovery of IID432: A highly efficacious and safe cyanotriazole inhibitor of Trypanosoma cruzi topoisomerase II for short-duration curative treatment of Chagas disease. ACS. 2025 Aug 20.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo II
Curated Selection
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