TFAM activator 1

TFAM activator 1 (Compound 2) is a Transcription Factor A, Mitochondrial (TFAM) activator. TFAM activator 1 has an anti-inflammatory and mitochondrial dysfunction restoration activity. TFAM activator 1 increases TFAM protein levels and mtDNA copy number and inhibits mtDNA stress-mediated inflammatory responses with reduced cytokine (TNF-α, CXCL-10 and IFN) production by preventing mtDNA escape into the cytosol. TFAM activator 1 significantly increases ATP level, reduces fibrotic markers and enhances Treg 240 function. TFAM activator 1 can be used for mitochondrial dysfunction, such as Parkinson’s and Alzheimer’s diseases research[1].