Factor XI-IN-2
Factor XI-IN-2 is a Factor XI activation inhibitor with an IC50 of 20 nM. Factor XI-IN-2 does not directly inhibit the enzymatic activity of FXIa, but specifically binds to the FXI enzyme precursor and allosterically inhibits the process by which it is activated by FXIIa. Factor XI-IN-2 inhibits thrombosis in the rabbit arteriovenous (AV) shunt thrombosis model. Factor XI-IN-2 can be used for the study of antithrombus[1].
Product Specifications
CAS Number
[2563884-39-7]
UNSPSC
12352005
Target
Factor XI
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Smiles
O=C(N1CCCCC1)C2=CC(C(N3CCC(CC3)N4C=CC=N4)=O)=NC5=CC=C(C=C52)OCC6=CC=C7SN=NC7=C6
Molecular Formula
C31H31N7O3S
Molecular Weight
581.69
References & Citations
[1]Ellsworth, Ken, et al. The Discovery of a Novel Anticoagulant Mechanism: Factor XI Activation Inhibitors. ACS Pharmacology & Translational Science (2025) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 4
Curated Selection
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