PI3Kδ-IN-26
PI3Kδ-IN-26 (Compound 58) is a selective and orally active PI3Kδ inhibitor with an IC50 of 14 nM. PI3Kδ-IN-26 significantly attenuates the inflammatory responses in house dust mite (HDM) induced chronic asthma mouse models. PI3Kδ-IN-26 can be used for inflammatory, autoimmune and hyperproliferative diseases research[1].
Product Specifications
CAS Number
2019131-11-2
UNSPSC
12352005
Target
PI3K
Related Pathways
PI3K/Akt/mTOR
Field of Research
Inflammation/Immunology
Smiles
CN1C=C(C=N1)C2=NC3=C(C(N4CCOCC4)=N2)N=C(N3)C(N5CCC(CC5)N6CCOCC6)=O
Molecular Formula
C23H31N9O3
Molecular Weight
481.55
References & Citations
[1]SAMBY K K, et al. 6-morpholinyl-2-pyrazolyl-9h-purine derivatives and their use as pi3k inhibitors. WO2016157074A1. 2016-10-06.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
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