PI4Kβ-IN-1
PI4Kβ-IN-1 is an orally active and selective PI4Kβ inhibitor, with an IC50 of 0.9 nM. PI4Kβ-IN-1 exhibits inhibitory activity against all stages of the P. falciparum life cycle, including blood, liver, and transmission stages. PI4Kβ-IN-1 demonstrates potent antimalarial efficacy in the mouse model infected with Plasmodium falciparum. PI4Kβ-IN-1 can be used for the study of malaria caused by Plasmodium falciparum[1].
Product Specifications
UNSPSC
12352005
Target
Parasite; PI4K
Related Pathways
Anti-infection; PI3K/Akt/mTOR
Field of Research
Infection
Smiles
O=C(N1C2CCOCC2)N(C)C3=C1C4=CC(C5=CC=CN=C5C)=CC=C4N=C3
Molecular Formula
C22H22N4O2
Molecular Weight
374.44
References & Citations
[1]Dziwornu GA, et al. Novel Inhibitors of Plasmodium Phosphatidylinositol 4-kinase IIIβ with Low Propensity for Resistance: Life Cycle Stage Activity and In Vivo Efficacy in a Humanized Mouse Malaria Infection Model. J Med Chem. 2025 Aug 28;68 (16) :17736-17751.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI4KIIIβ
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