PI4Kβ-IN-1

PI4Kβ-IN-1 is an orally active and selective PI4Kβ inhibitor, with an IC50 of 0.9 nM. PI4Kβ-IN-1 exhibits inhibitory activity against all stages of the P. falciparum life cycle, including blood, liver, and transmission stages. PI4Kβ-IN-1 demonstrates potent antimalarial efficacy in the mouse model infected with Plasmodium falciparum. PI4Kβ-IN-1 can be used for the study of malaria caused by Plasmodium falciparum[1].

Product Specifications

UNSPSC

12352005

Target

Parasite; PI4K

Related Pathways

Anti-infection; PI3K/Akt/mTOR

Field of Research

Infection

Smiles

O=C(N1C2CCOCC2)N(C)C3=C1C4=CC(C5=CC=CN=C5C)=CC=C4N=C3

Molecular Formula

C22H22N4O2

Molecular Weight

374.44

References & Citations

[1]Dziwornu GA, et al. Novel Inhibitors of Plasmodium Phosphatidylinositol 4-kinase IIIβ with Low Propensity for Resistance: Life Cycle Stage Activity and In Vivo Efficacy in a Humanized Mouse Malaria Infection Model. J Med Chem. 2025 Aug 28;68 (16) :17736-17751.