FabX-IN-1
FabX-IN-1 (Compound 47) is a selective FabX inhibitor with an IC50 of 0.128 μM. FabX-IN-1 has a narrow-spectrum antibacterial activity against Helicobacter pylori with a MIC of 64 μg/mL, but significantly enhances synergistic inhibitory efficacy combined with membrane permeabilizers, efflux pump inhibitors, and Clarithromycin (HY-17508) . FabX-IN-1 can be used for bacterial infections research[1].
Product Specifications
UNSPSC
12352100
Target
Bacterial
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Smiles
O=C(NC1=NN=C(S(=O)(NC2=CC=CC(N(C)C)=C2)=O)S1)C3=CC=C4C=CC=CC4=C3
Molecular Formula
C21H19N5O3S2
Molecular Weight
453.54
References & Citations
[1]Ruan X, et al. Discovery of 1,3,4-Thiadiazole Sulfonamide-Based Potent Inhibitors against the Unsaturated Fatty Acid Synthase FabX of Helicobacter pylori. J Med Chem. 2025 Aug 28;68 (16) :17175-17188.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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