Cyclin A/B RxL-IN-1

Cyclin A/B RxL-IN-1 is a inhibitor targeting the Cyclin A/B RxL interaction at the hydrophobic patch (HP) . Cyclin A/B RxL-IN-1 inhibits Cyclin A with an IC50 of 0.12 μM. Cyclin A/B RxL-IN-1 demonstrates antitumor efficacy in mouse cell line-derived xenograft (CDX) models. CDK-IN-19 can be used for the study of E2F-driven cancers such as small-cell lung cancer (SCLC) [1].

Product Specifications

CAS Number

[3036231-62-3]

UNSPSC

12352005

Target

CDK

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

CC(C[C@@H]1NC([C@H](CCCCNC(C(C)(NC([C@@H](N(C1=O)C)CC2=CC(Cl)=CC=C2Cl)=O)C)=O)N(C([C@H](C3CC3)NC([C@@H]4C[C@H](CN4C(C5(CC6(C5)CCC6)C(F)(F)F)=O)F)=O)=O)C)=O)C

Molecular Formula

C46H63Cl2F4N7O7

Molecular Weight

972.93

References & Citations

[1]Bockus AT, et al. Discovery of Cell-Permeable Macrocyclic Cyclin A/B RxL Inhibitors that Demonstrate Antitumor Activity. J Med Chem. 2025 Aug 28;68 (16) :17030-17045.