NR4A1 agonist 1
NR4A1 agonist 1 is a NR4A1 agonist with a Ki value of 2.96 μM. NR4A1 agonist 1 exhibits lipid-lowering activity in 3T3-L1 adipocytes, with an EC50 of 0.13 μM, significantly decreasing triglyceride (TG) accumulation and lipid droplet accumulation. NR4A1 agonist 1 can be used for the study of obesity[1].
Product Specifications
CAS Number
1825366-87-7
UNSPSC
12352005
Target
Nuclear Hormone Receptor 4A/NR4A
Related Pathways
Vitamin D Related/Nuclear Receptor
Field of Research
Metabolic Disease
Smiles
CN(CCCNC1=NC(C2=C(C3=CC=CC=C3N2)C=O)=NC4=C1C=CC=C4)C
Molecular Formula
C22H23N5O
Molecular Weight
373.45
References & Citations
[1]Hu YT, et al. Identification of Indoquinazoline Derivatives as Novel NR4A1 Agonists by Suppressing Adipocyte Lipogenesis for Treatment of Obesity. J Med Chem. 2025 Aug 28;68 (16) :17364-17377.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
35929121 3x 1.0µg DNA
PADI6 CRISPRa sgRNA lentivector (set of three targets)(Human)
Sign In for Pricing
View Details 
MBS6141433-01 0.1 mL
Cyclophilin E (Cyclophilin 33, CYP33, CYP-33, MGC3736, MGC111222, Peptidyl-Prolyl Cis-Trans Isomerase E, PPIase E, PPIE, Rotamase E, Rotamase-E) (Biotin)
Sign In for Pricing
View Details MBS6141433-02 5x 0.1 mL
Cyclophilin E (Cyclophilin 33, CYP33, CYP-33, MGC3736, MGC111222, Peptidyl-Prolyl Cis-Trans Isomerase E, PPIase E, PPIE, Rotamase E, Rotamase-E) (Biotin)
Sign In for Pricing
View Details 
GTR10324565 96 Well
Human F box/WD repeat containing protein 9 (FBXW9) ELISA Kit
Sign In for Pricing
View Details