NR4A1 agonist 1
NR4A1 agonist 1 is a NR4A1 agonist with a Ki value of 2.96 μM. NR4A1 agonist 1 exhibits lipid-lowering activity in 3T3-L1 adipocytes, with an EC50 of 0.13 μM, significantly decreasing triglyceride (TG) accumulation and lipid droplet accumulation. NR4A1 agonist 1 can be used for the study of obesity[1].
Product Specifications
CAS Number
[1825366-87-7]
UNSPSC
12352005
Target
Nuclear Hormone Receptor 4A/NR4A
Related Pathways
Vitamin D Related/Nuclear Receptor
Field of Research
Metabolic Disease
Smiles
CN(CCCNC1=NC(C2=C(C3=CC=CC=C3N2)C=O)=NC4=C1C=CC=C4)C
Molecular Formula
C22H23N5O
Molecular Weight
373.45
References & Citations
[1]Hu YT, et al. Identification of Indoquinazoline Derivatives as Novel NR4A1 Agonists by Suppressing Adipocyte Lipogenesis for Treatment of Obesity. J Med Chem. 2025 Aug 28;68 (16) :17364-17377.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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