MBL-IN-6

MBL-IN-6 (Compound 6d) is a Metallo-β-lactamase (MBL) inhibitor with Kis of 2.6 and 0.08 μM for NDM-1 and VIM-2, respectively. MBL-IN-6 has a synergistic activities with Imipenem (HY-B1369A) on MBL-producing clinical isolates (such as E. coli SI-M001, K. pneumonia T2301 and S. marcescens SI-1591) with MICs of 2-64 μg/mL. MBL-IN-6 does not have off-target effects without ACE-1 inhibition activity. MBL-IN-6 can be used for antimicrobial resistance research[1].

Product Specifications

UNSPSC

12352005

Target

Bacterial; Beta-lactamase

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

O=C(N)[C@@H]1N(C2=CC=CC=C2C1(CC)CC)C([C@@H](CS)C)=O

Molecular Formula

C17H24N2O2S

Molecular Weight

320.45

References & Citations

[1]Alfano AI, et al. Sustainable Joullié-Ugi and Continuous Flow Implementation Led to Novel Captopril-Inspired Broad-Spectrum Metallo-β-Lactamase Inhibitors. J Med Chem. 2025 Aug 28;68 (16) :17236-17257.