MAO-A/B-IN-4

MAO-A/B-IN-4 is an orally active MAO-A/B inhibitor, with IC50 values of 51.3 μM and 47.0 μM, respectively. MAO-A/B-IN-4 exhibits potent activity against S. aureus, MSSA, MRSA, LRSA, and LREFa. MAO-A/B-IN-4 demonstrates potent antibacterial efficacy in a mouse model of LRSA peritonitis infection. MAO-A/B-IN-4 can be used for the study of bacterial infections[1].

Product Specifications

UNSPSC

12352005

Target

Bacterial; Monoamine Oxidase

Related Pathways

Anti-infection; Neuronal Signaling

Field of Research

Infection

Smiles

O=C1O[C@H](CN1C2=CC(F)=C(C(F)=C2)C3=CN=C(C=C3)/C=N/N4CCOCC4)CN5C=CN=N5

Molecular Formula

C22H21F2N7O3

Molecular Weight

469.44

References & Citations

[1]Duan M, et al. Multiparameter Optimization of Broad-Spectrum Antibacterial Activity, ADMET Properties, and MAO-A/B Inhibition of Novel Biaryloxazolidinone-Hydrazone Derivatives: Identification of a Lead with In Vivo Efficacy against Linezolid-Resistant Staphylococcus aureus. J Med Chem. 2025 Aug 28;68 (16) :16958-16988.