SRD5A1-IN-2
SRD5A1-IN-2 is a inhibitor of steroid 5α-reductase type-1 (SRD5A1), with an IC50 of 8.5 μM. SRD5A1-IN-2 downregulates SRD5A1 protein expression in HaCaT cells. SRD5A1-IN-2 reduces dihydrotestosterone (DHT) production in HaCaT cells. SRD5A1-IN-2 can be used for the study of androgen-related conditions such as androgenetic alopecia (AGA) [1].
Product Specifications
UNSPSC
12352005
Target
5 alpha Reductase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Endocrinology
Smiles
COC1=C(C=CC(/C=C/C(OC2=C(C=CC(C(F)(F)F)=C2)C(F)(F)F)=O)=C1)O
Molecular Formula
C18H12F6O4
Molecular Weight
406.28
References & Citations
[1]Isswanich K, et al. Natural Product-Inspired Bis (trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies. ACS Omega. 2025 Aug 13;10 (33) :38211-38228.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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