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Tubulin/CDC5L-IN-1

Tubulin/CDC5L-IN-1 is a Tubulin/CDC5L dual inhibitor. Tubulin/CDC5L-IN-1 targets to CDCL5 with a KD of 103.7 μM. Tubulin/CDC5L-IN-1 can inhibit multiple cancer cell proliferation and induce G2/M phase arrest. Tubulin/CDC5L-IN-1 induce cell apoptosis and ROS production. Tubulin/CDC5L-IN-1 exhibits antiangiogenic effects. Tubulin/CDC5L-IN-1 can be used for the research of cancer, such as colon carcinoma[1].

Product Specifications

CAS Number

3050832-41-9

UNSPSC

12352005

Target

Apoptosis; Microtubule/Tubulin; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

CC(C)C[C@H](C(O)=O)NC(OC1=CC(C2=NC(N)=C3C(N(C4=CC(OC)=C(OC)C(OC)=C4)N=C3)=N2)=CC=C1OC)=O

Molecular Formula

C28H32N6O8

Molecular Weight

580.59

References & Citations

[1]Shi Z, et al. Novel Diaryl-Substituted Pyrazolo[3,4-d]pyrimidines as Tubulin/CDC5L Dual-Targeting Ligands: Discovery, Potent Antitumor Activity, and Good Metabolic Stability. J Med Chem. 2025 Aug 28;68 (16) :17258-17286.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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