PD-1/PD-L1-IN-57
PD-1/PD-L1-IN-57 (Compound J29) is a PD-1/PD-L1 inhibitor with an IC50 of 5.5 nM. PD-1/PD-L1-IN-57 has a strong immunoregulatory activity, effectively promotes T-cell proliferation and restores the killing ability of tumor cells. PD-1/PD-L1-IN-57 can be used for tumor immunotherapy research[1].
Product Specifications
UNSPSC
12352005
Target
PD-1/PD-L1
Related Pathways
Immunology/Inflammation
Field of Research
Cancer; Inflammation/Immunology
Smiles
OC[C@H](C(O)=O)NCC1=CC(C(N2CCC3=C2C=CC=C3C4=CC=CC=C4)=O)=NN1C
Molecular Formula
C23H24N4O4
Molecular Weight
420.46
References & Citations
[1]Deng W, et al. Discovery of Pyrazole-Containing 4-Arylindolines as Potent Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction[J]. ACS Medicinal Chemistry Letters, 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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